PRUNE1

Across TCGA pan-cancer cohorts, PRUNE1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PRUNE1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRUNE1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PRUNE1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where PRUNE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.344	1.000	.009	39	view →
CCRCC	DFS	Tertile	II,III,IV	0.959	0.064	.008	24	view →
UCEC	DFS	Median	II,III,IV	0.469	0.944	.003	12	view →
LUAD	OS	Median	III,IV	0.330	0.869	.006	12	view →
GBM	OS	Quartile	All	0.421	0.763	.015	6	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	6	view →
LSCC	OS	Tertile	II,III,IV	0.775	1.000	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PRUNE1–HNSC (OS)

Open the HNSC breakdown →