PRUNE1

Across TCGA patient cohorts, PRUNE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,654 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRUNE1-associated proteins across cancer lineages are RPRD2, BROX, and C1orf35. Each is linked with PRUNE1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRUNE1-to-partner and partner-to-PRUNE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRUNE1 versus RPRD2 in LSCC, with a Pearson correlation of 0.79.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE1→partner) and Y-score (partner→PRUNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPRD2 →	+0.352	+0.688	<.001	<.001	3	9
LSCC	BROX →	+0.503	+0.732	<.001	<.001	3	9
LSCC	C1orf35 →	+0.499	+0.589	<.001	<.001	3	8
LSCC	CDC73 →	+0.302	+0.658	<.001	<.001	3	8
LSCC	GATAD2B →	+0.313	+0.592	<.001	<.001	3	8
LSCC	POGZ →	+0.340	+0.688	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,654 associations by consensus.

PRUNE1 vs RPRD2 — LSCC

Explore this scatter interactively →