PRUNE1

Across TCGA patient cohorts, PRUNE1 mutation is significantly associated with the RNA expression of many other genes, with 678 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRUNE1-associated genes across cancer lineages are LINC01941, RNU6-255P, and LINC02871. Each is linked with PRUNE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRUNE1-to-partner and partner-to-PRUNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01941 grouped by PRUNE1-low versus PRUNE1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE1→partner) and Y-score (partner→PRUNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01941 →	+0.241	+5.575	<.001	.004	3	2
LUSC	RNU6-255P →	+0.512	+5.474	<.001	.005	3	2
SKCM	LINC02871 →	+0.112	+4.495	<.001	.007	3	1
SKCM	H2BC1 →	+0.075	+4.884	.005	.004	3	1
BRCA	RNU6-993P →	+0.546	+5.259	<.001	.007	3	1
BRCA	IGLV3-7 →	+0.187	+5.409	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 678 associations by consensus.

LINC01941 by PRUNE1 expression — BRCA

Explore this box plot interactively →