PRUNE1

Across TCGA patient cohorts, PRUNE1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRUNE1-associated genes across cancer lineages are eIF4E, Notch1, and p62 Lck ligand. Each is linked with PRUNE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRUNE1-to-partner and partner-to-PRUNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PRUNE1-low versus PRUNE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE1→partner) and Y-score (partner→PRUNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.219	+3.321	.047	.010	3	1
UCEC	Notch1 →	+0.275	+3.335	<.001	.005	3	1
UCEC	p62 Lck ligand →	+0.336	+2.817	.048	.036	3	1
UCEC	PDCD4 →	-0.695	-2.999	.004	.035	3	1
UCEC	PKC-delta_pS664 →	-0.188	-3.160	.002	.019	3	1
UCEC	PKC-b-II_pS660 →	-0.382	-3.000	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4E by PRUNE1 expression — UCEC

Explore this box plot interactively →