PRUNE1

Across TCGA cell cohorts, PRUNE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,349 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRUNE1-associated GO terms across cancer lineages are Positive regulation of stem cell population maintenance, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, and mRNA 3'-end processing. Each is linked with PRUNE1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PRUNE1-to-partner and partner-to-PRUNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of stem cell population maintenance grouped by PRUNE1-low versus PRUNE1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE1→partner) and Y-score (partner→PRUNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of stem cell population maintenance →	+0.065	+0.688	<.001	<.001	3	14
BONE	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.125	+1.012	<.001	<.001	3	13
SOFT_TISSUE	mRNA 3'-end processing →	+0.078	+0.612	<.001	<.001	3	13
STOMACH	Epigenetic regulation of gene expression →	+0.054	+0.610	<.001	.002	3	13
OVARY	Nucleic acid transport →	+0.098	+1.005	<.001	<.001	3	13
OVARY	RNA transport →	+0.098	+1.005	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,349 associations by consensus.

Positive regulation of stem cell population maintenance by PRUNE1 expression — STOMACH

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