PRTFDC1

Across TCGA patient cohorts, PRTFDC1 mutation is significantly associated with the RNA expression of many other genes, with 471 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRTFDC1-associated genes across cancer lineages are RNU6-939P, RN7SKP286, and RNA5SP519. Each is linked with PRTFDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRTFDC1-to-partner and partner-to-PRTFDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-939P grouped by PRTFDC1-low versus PRTFDC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRTFDC1→partner) and Y-score (partner→PRTFDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-939P →	+0.587	+5.508	<.001	<.001	3	2
UCEC	RN7SKP286 →	+0.040	+3.890	<.001	.007	3	2
UCEC	RNA5SP519 →	+0.448	+2.398	<.001	.004	3	2
UCEC	CCDC163 →	+0.560	+3.600	<.001	.001	3	1
UCEC	DNAJB5-DT →	+0.403	+2.840	<.001	.002	3	1
CESC	BNIP3P2 →	+0.056	+5.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 471 associations by consensus.

RNU6-939P by PRTFDC1 expression — SKCM

Explore this box plot interactively →