PRSS58

Across TCGA pan-cancer cohorts, PRSS58 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated PRSS58 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRSS58 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS58 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD, HNSC, and LIHC are the cancer types where PRSS58 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.806	.002	24	view →
HNSC	OS	Median	II,III,IV	0.086	0.711	<.001	20	view →
LIHC	DFS	Median	All	0.107	0.545	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUAD	OS	Median	III,IV	0.153	0.690	<.001	12	view →
STAD	DFS	Median	All	0.118	0.630	.001	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	6	view →
SKCM	OS	Median	All	0.846	0.359	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

PRSS58–COAD (OS)

Open the COAD breakdown →