Across TCGA pan-cancer cohorts, PRSS57 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRSS57 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PRSS57 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS57 expression acts as an unfavorable survival marker.

LGG, READ, and LIHC are the cancer types where PRSS57 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.240	0.830	<.001	12	view →
READ	DFS	Median	All	0.111	0.820	<.001	12	view →
LIHC	OS	Median	All	0.015	0.784	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PRSS57 tumor-vs-normal RNA expression · all PRSS57 data types