Across TCGA patient cohorts, PRSS57 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS57-associated genes across cancer lineages are eIF4E, eIF4G, and HER3. Each is linked with PRSS57 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS57-to-partner and partner-to-PRSS57 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS57→partner) and Y-score (partner→PRSS57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.204	+2.584	.037	.011	3	2
UCEC	eIF4G →	+0.302	+2.584	.037	.011	3	1
UCEC	HER3 →	+0.296	+2.820	.020	.035	3	1
UCEC	PDK1 →	+0.120	+2.584	.016	.011	3	1
UCEC	Annexin-1 →	+0.906	+2.584	<.001	.011	3	1
UCEC	TIGAR →	+0.199	+3.727	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

PRSS57 survival (RNA) · tumor vs normal (RNA) · all PRSS57 data types