PRSS56

Across TCGA patient cohorts, PRSS56 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,346 significant associations in total. LGG shows the largest number of these associations.

The most reproducible PRSS56-associated GO terms across cancer lineages are Regulation of animal organ morphogenesis, Negative regulation of Notch signaling pathway, and Establishment of tissue polarity. Each is linked with PRSS56 in more than 7 cancer types. Because this analysis shows association rather than direction, both PRSS56-to-partner and partner-to-PRSS56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of animal organ morphogenesis grouped by PRSS56-low versus PRSS56-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS56→partner) and Y-score (partner→PRSS56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Regulation of animal organ morphogenesis →	+0.079	+0.314	<.001	.002	3	8
TGCT	Negative regulation of Notch signaling pathway →	+0.039	+0.182	<.001	.003	2	8
TGCT	Establishment of tissue polarity →	+0.057	+0.176	<.001	.004	3	7
TGCT	Negative regulation of canonical Wnt signaling pathway →	+0.050	+0.226	<.001	.007	3	7
TGCT	Obsolete histone ubiquitination →	+0.054	+0.130	<.001	.001	3	7
TGCT	Positive regulation of non-canonical Wnt signaling pathway →	+0.087	+0.176	<.001	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,346 associations by consensus.

Regulation of animal organ morphogenesis by PRSS56 expression — TGCT

Explore this box plot interactively →