PRSS53

Across TCGA patient cohorts, PRSS53 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS53-associated genes across cancer lineages are PCNA, ARID1A, and EGFR. Each is linked with PRSS53 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS53-to-partner and partner-to-PRSS53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PRSS53-low versus PRSS53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS53→partner) and Y-score (partner→PRSS53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.177	+2.321	.047	.006	3	2
UCEC	ARID1A →	-0.167	-1.800	.026	.027	3	2
UCEC	EGFR →	-0.158	-1.807	.016	.027	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.321	.001	.010	3	1
UCEC	ERK2 →	+0.195	+2.459	.014	.018	3	1
UCEC	MEK1 →	+0.297	+2.459	.049	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PCNA by PRSS53 expression — UCEC

Explore this box plot interactively →