PRSS53

Across TCGA cell cohorts, PRSS53 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,230 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRSS53-associated GO terms across cancer lineages are Microtubule polymerization, Calcium-independent cell-matrix adhesion, and Subtelomeric heterochromatin formation. Each is linked with PRSS53 in more than 16 cancer types. Because this analysis shows association rather than direction, both PRSS53-to-partner and partner-to-PRSS53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization grouped by PRSS53-low versus PRSS53-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS53→partner) and Y-score (partner→PRSS53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Microtubule polymerization →	+0.113	+1.110	<.001	<.001	3	17
BONE	Calcium-independent cell-matrix adhesion →	+0.221	+0.843	<.001	<.001	3	17
BONE	Subtelomeric heterochromatin formation →	+0.143	+0.811	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.089	+0.640	<.001	<.001	3	16
OVARY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.143	+0.594	<.001	.006	3	16
KIDNEY	Chiasma assembly →	+0.220	+0.904	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

Microtubule polymerization by PRSS53 expression — BREAST

Explore this box plot interactively →