PRSS51

Across TCGA pan-cancer cohorts, PRSS51 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PRSS51’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRSS51 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS51 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where PRSS51 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS51 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.297	<.001	11	view →
BRCA	All	III,IV	−1.035	<.001	8	view →
COAD	All	All	+0.761	<.001	7	view →
STAD	All	All	+0.765	.002	6	view →
UCEC	All	IV	+1.785	<.001	4	view →
THCA	All	II,III,IV	−0.216	.009	4	view →
PAAD	All	All	+1.765	.034	2	view →
LIHC	All	All	+0.344	.022	2	view →
LUAD	Male	II,III,IV	+0.682	.049	1	view →
KICH	All	All	−0.120	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PRSS51–KIRC

Open the KIRC breakdown →