Across TCGA pan-cancer cohorts, PRSS45P RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PRSS45P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRSS45P RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRSS45P expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UCS, and PAAD are the cancer types where PRSS45P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.842	0.611	.001	47	view →
UCS	DFS	Quartile	III,IV	0.540	0.190	.022	30	view →
PAAD	OS	Median	II,III,IV	0.457	0.275	.005	30	view →
COAD	DFS	Median	II,III,IV	0.555	0.723	.004	26	view →
UCEC	DFS	Tertile	IV	0.858	0.463	.011	26	view →
BLCA	DFS	Tertile	II,III,IV	0.476	0.301	.010	20	view →
SARC	DFS	Median	All	0.679	0.542	.004	20	view →
STAD	OS	Median	IV	0.642	0.194	.003	15	view →
LGG	DFS	Tertile	All	0.301	0.442	.004	10	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	10	view →
ACC	OS	Median	IV	0.758	0.348	.011	9	view →
KIRP	DFS	Quartile	IV	0.676	0.456	.038	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

Exploration

Same gene, other analysis: PRSS45P tumor-vs-normal RNA expression · all PRSS45P data types