PRSS36

Across TCGA patient cohorts, PRSS36 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS36-associated genes across cancer lineages are Cyclin-B1, Notch1, and p62 Lck ligand. Each is linked with PRSS36 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS36-to-partner and partner-to-PRSS36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PRSS36-low versus PRSS36-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS36→partner) and Y-score (partner→PRSS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.532	+2.321	.008	.035	3	2
UCEC	Notch1 →	+0.226	+2.179	<.001	.034	3	1
UCEC	p62 Lck ligand →	+0.469	+3.009	.002	.019	3	1
UCEC	PKC-a →	+0.429	+2.820	.028	.035	3	1
UCEC	Shc_pY317 →	-0.168	-2.459	.022	.020	3	1
UCEC	STAT5a →	+0.444	+3.000	.021	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Cyclin-B1 by PRSS36 expression — SKCM

Explore this box plot interactively →