PRSS36

Across TCGA cell cohorts, PRSS36 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,596 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRSS36-associated GO terms across cancer lineages are Lysosomal lumen acidification, Regulation of proteasomal protein catabolic process, and Positive regulation of protein localization to cell periphery. Each is linked with PRSS36 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRSS36-to-partner and partner-to-PRSS36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by PRSS36-low versus PRSS36-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS36→partner) and Y-score (partner→PRSS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Lysosomal lumen acidification →	+0.078	+0.835	<.001	<.001	3	9
OVARY	Regulation of proteasomal protein catabolic process →	+0.044	+0.493	<.001	<.001	3	9
OVARY	Positive regulation of protein localization to cell periphery →	+0.096	+0.587	<.001	<.001	3	9
OVARY	Negative regulation of myoblast fusion →	+0.104	+0.494	<.001	<.001	3	9
OVARY	Regulation of myoblast fusion →	+0.101	+0.565	<.001	<.001	3	9
URINARY_TRACT	Flagellated sperm motility →	-0.134	-0.950	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,596 associations by consensus.

Lysosomal lumen acidification by PRSS36 expression — BLOOD_Leukemia

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