PRSS36

Across TCGA cell cohorts, PRSS36 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRSS36-associated genes across cancer lineages are SYT10, PRAMEF1, and EDDM3B. Each is linked with PRSS36 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS36-to-partner and partner-to-PRSS36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYT10 grouped by PRSS36-low versus PRSS36-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS36→partner) and Y-score (partner→PRSS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYT10 →	+0.251	+3.076	.006	.002	3	2
STOMACH	PRAMEF1 →	+0.017	+3.432	.003	.008	3	2
PANCREAS	EDDM3B →	+0.015	+4.614	<.001	.004	3	1
PANCREAS	ANKRD66 →	+0.013	+4.237	.001	.006	3	1
BLOOD_Lymphoma	LCN9 →	+0.030	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	PROP1 →	+0.012	+4.867	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

SYT10 by PRSS36 expression — BLOOD_Leukemia

Explore this box plot interactively →