PRSS3

Across TCGA pan-cancer cohorts, PRSS3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRSS3 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRSS3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS3 expression acts as an unfavorable survival marker.

COAD, STAD, and KIRP are the cancer types where PRSS3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.001	0.871	<.001	24	view →
STAD	OS	Median	All	0.184	0.730	.001	18	view →
KIRP	OS	Median	All	0.733	0.903	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PRSS3–COAD (OS)

Open the COAD breakdown →