PRSS3

Across TCGA cell cohorts, PRSS3 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PRSS3-associated genes across cancer lineages are MTRNR2L6, SLC9C2, and PRSS1. Each is linked with PRSS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS3-to-partner and partner-to-PRSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by PRSS3-low versus PRSS3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS3→partner) and Y-score (partner→PRSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MTRNR2L6 →	+0.025	+3.017	<.001	.006	3	2
LUNG_SCLC	SLC9C2 →	+0.142	+3.339	<.001	.007	3	2
LUNG_SCLC	PRSS1 →	+2.546	+3.691	<.001	.002	3	2
BLOOD_Myeloma	LATS1 →	-0.769	-3.000	<.001	.005	3	1
BLOOD_Myeloma	SOST →	+0.010	+2.459	<.001	.003	3	1
BLOOD_Myeloma	RGL3 →	+1.997	+3.044	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

MTRNR2L6 by PRSS3 expression — OVARY

Explore this box plot interactively →