Across TCGA pan-cancer cohorts, PRSS29P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRSS29P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where PRSS29P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS29P is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.
THCA, BRCA, and KIRP are the cancer types where PRSS29P tumor–normal differential expression is most reproducible.