PRSS27

Across TCGA pan-cancer cohorts, PRSS27 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRSS27 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PRSS27 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRSS27 expression acts as an unfavorable survival marker.

ACC, UCEC, and PRAD are the cancer types where PRSS27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
PRAD	DFS	Median	All	0.617	0.886	.038	6	view →
LUSC	OS	Median	All	0.196	0.675	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRSS27–ACC (DFS)

Open the ACC breakdown →