PRSS27

Across TCGA patient cohorts, PRSS27 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS27-associated genes across cancer lineages are IGFBP2, Ku80, and Myosin-IIa_pS1943. Each is linked with PRSS27 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS27-to-partner and partner-to-PRSS27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by PRSS27-low versus PRSS27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS27→partner) and Y-score (partner→PRSS27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.696	-3.000	.014	.036	3	1
UCEC	Ku80 →	+0.283	+2.128	.006	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.246	+2.820	.006	.001	3	1
UCEC	PCNA →	+0.237	+2.115	.012	.019	3	1
UCEC	Rab25 →	-0.446	-2.115	.002	.019	3	1
UCEC	VHL →	-1.019	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IGFBP2 by PRSS27 expression — UCEC

Explore this box plot interactively →