PRSS23

Across TCGA pan-cancer cohorts, PRSS23 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRSS23’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRSS23 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PRSS23 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, PDAC, and HNSC are the cancer types where PRSS23 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS23 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.608	<.001	9	view →
PDAC	Male	All	+0.793	<.001	8	view →
HNSC	Male	III,IV	+0.487	.001	6	view →
CCRCC	Male	All	−0.344	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRSS23–COAD

Open the COAD breakdown →