PRSS22

Across TCGA patient cohorts, PRSS22 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,744 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRSS22-associated proteins across cancer lineages are PPL, PPL_S830, and SH2D3A_S180. Each is linked with PRSS22 in more than 6 cancer types. Because this analysis shows association rather than direction, both PRSS22-to-partner and partner-to-PRSS22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRSS22 versus PPL in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS22→partner) and Y-score (partner→PRSS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPL →	+0.808	+1.510	<.001	<.001	3	7
UCEC	PPL_S830 →	+0.919	+1.135	<.001	<.001	3	5
BRCA	SH2D3A_S180 →	+0.614	+0.717	<.001	<.001	3	5
LSCC	ARHGEF5 →	+0.325	+1.068	.003	.001	3	4
LSCC	S100P →	+1.001	+1.218	<.001	<.001	3	4
LSCC	SFN →	+0.960	+1.480	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,744 associations by consensus.

PRSS22 vs PPL — HNSC

Explore this scatter interactively →