PRSS22

Across TCGA patient cohorts, PRSS22 protein abundance is significantly associated with the RNA expression of many other genes, with 7,532 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PRSS22-associated genes across cancer lineages are S100P, DEFB1, and BCAS1. Each is linked with PRSS22 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRSS22-to-partner and partner-to-PRSS22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRSS22 versus S100P in UCEC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS22→partner) and Y-score (partner→PRSS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S100P →	+3.629	+0.993	<.001	<.001	3	5
UCEC	DEFB1 →	+2.285	+0.865	.003	<.001	3	4
BRCA	BCAS1 →	+2.331	+0.727	<.001	.004	3	4
UCEC	RAB9B →	-0.777	-0.635	.001	.004	3	3
UCEC	PI3 →	+2.778	+0.635	.001	.002	3	3
UCEC	ADAMTS3 →	-0.876	-0.723	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,532 associations by consensus.

PRSS22 vs S100P — UCEC

Explore this scatter interactively →