PRSS22

Across TCGA cell cohorts, PRSS22 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,419 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRSS22-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Rho protein signal transduction, and Regulation of protein import into nucleus. Each is linked with PRSS22 in more than 11 cancer types. Because this analysis shows association rather than direction, both PRSS22-to-partner and partner-to-PRSS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by PRSS22-low versus PRSS22-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS22→partner) and Y-score (partner→PRSS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.056	+3.545	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.121	+2.908	<.001	<.001	3	12
PANCREAS	Regulation of protein import into nucleus →	+0.117	+3.499	<.001	<.001	3	12
URINARY_TRACT	Regulation of hippocampal neuron apoptotic process →	+1.842	+4.054	<.001	<.001	3	11
STOMACH	Positive regulation of intracellular mRNA localization →	+0.214	+3.297	<.001	<.001	3	11
BREAST	Negative regulation of actin filament polymerization →	+0.145	+2.121	<.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,419 associations by consensus.

Small GTPase-mediated signal transduction by PRSS22 expression — URINARY_TRACT

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