PRSS22

Across TCGA cell cohorts, PRSS22 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PRSS22-associated genes across cancer lineages are OR52H1, FAM205A, and ASB17. Each is linked with PRSS22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS22-to-partner and partner-to-PRSS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52H1 grouped by PRSS22-low versus PRSS22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS22→partner) and Y-score (partner→PRSS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR52H1 →	+0.020	+3.347	.003	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+3.614	<.001	.006	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	DAZ2 →	+0.080	+4.807	<.001	.003	3	1
OVARY	CT47A6 →	+0.022	+4.807	<.001	.003	3	1
OVARY	TAS2R39 →	+0.022	+4.990	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR52H1 by PRSS22 expression — LARGE_INTESTINE

Explore this box plot interactively →