PRSS22

Across TCGA cell cohorts, PRSS22 mutation is significantly associated with the mutation status of many other genes, with 5,023 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRSS22-associated genes across cancer lineages are SYNC, RASGEF1A, and TCF20. Each is linked with PRSS22 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRSS22-to-partner and partner-to-PRSS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNC grouped by PRSS22-low versus PRSS22-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS22→partner) and Y-score (partner→PRSS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYNC →	+6.321	+6.321	.001	.001	1	4
OVARY	RASGEF1A →	+4.977	+4.415	.007	.007	1	4
OVARY	TCF20 →	+3.240	+4.467	.004	.004	1	3
OVARY	TRMU →	+4.977	+4.415	.007	.007	1	3
OVARY	GMEB2 →	+4.977	+4.415	.007	.007	1	3
OVARY	JAG1 →	+4.562	+5.217	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,023 associations by consensus.

SYNC by PRSS22 expression — BLOOD_Leukemia

Explore this box plot interactively →