PRSS21

Across TCGA patient cohorts, PRSS21 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS21-associated genes across cancer lineages are aDC, Adipocytes, and Keratinocytes. Each is linked with PRSS21 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS21-to-partner and partner-to-PRSS21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, aDC grouped by PRSS21-low versus PRSS21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS21→partner) and Y-score (partner→PRSS21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	aDC →	+0.128	+2.815	.002	.036	3	1
UCEC	Adipocytes →	+0.040	+2.729	<.001	.009	3	1
UCEC	Keratinocytes →	+0.017	+3.128	.038	.016	3	1
UCEC	pDC →	+0.064	+3.008	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

aDC by PRSS21 expression — UCEC

Explore this box plot interactively →