PRSS21

Across TCGA cell cohorts, PRSS21 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,703 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRSS21-associated GO terms across cancer lineages are 2-oxoglutarate decarboxylation to succinyl-CoA, Nucleoside phosphate biosynthetic process, and Regulation of dendritic cell dendrite assembly. Each is linked with PRSS21 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRSS21-to-partner and partner-to-PRSS21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate decarboxylation to succinyl-CoA grouped by PRSS21-low versus PRSS21-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS21→partner) and Y-score (partner→PRSS21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.112	+2.612	.003	.008	3	5
BLOOD_Myeloma	Nucleoside phosphate biosynthetic process →	+0.039	+3.642	.002	.007	3	5
BLOOD_Leukemia	Regulation of dendritic cell dendrite assembly →	-0.629	-2.046	.008	.003	3	5
BLOOD_Leukemia	Germ-line stem cell population maintenance →	-0.116	-2.162	<.001	.005	3	5
BLOOD_Leukemia	C-C chemokine receptor CCR7 signaling pathway →	-0.629	-2.046	.008	.003	3	5
BLOOD_Myeloma	Purine-containing compound biosynthetic process →	+0.046	+3.542	.005	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,703 associations by consensus.

2-oxoglutarate decarboxylation to succinyl-CoA by PRSS21 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →