PRSS21

Across TCGA cell cohorts, PRSS21 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRSS21-associated genes across cancer lineages are CBY1, MREG, and KATNBL1. Each is linked with PRSS21 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS21-to-partner and partner-to-PRSS21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by PRSS21-low versus PRSS21-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS21→partner) and Y-score (partner→PRSS21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.777	+3.160	<.001	.006	3	1
LARGE_INTESTINE	MREG →	+0.672	+3.067	.001	.009	3	1
LARGE_INTESTINE	KATNBL1 →	+0.560	+3.082	.001	.007	3	1
LARGE_INTESTINE	GTF2B →	+0.487	+3.215	<.001	.009	3	1
LARGE_INTESTINE	UBE2Q2 →	+0.781	+3.215	.002	.009	3	1
LARGE_INTESTINE	SLC39A6 →	+1.088	+3.064	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CBY1 by PRSS21 expression — LARGE_INTESTINE

Explore this box plot interactively →