PRSS2

Across TCGA patient cohorts, PRSS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,711 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PRSS2-associated proteins across cancer lineages are RGS14, GTF3C4, and ARHGEF6_S640. Each is linked with PRSS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRSS2-to-partner and partner-to-PRSS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRSS2 versus RGS14 in HNSC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS2→partner) and Y-score (partner→PRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RGS14 →	+0.392	+0.711	<.001	.003	3	4
LSCC	GTF3C4 →	-0.239	-0.961	<.001	<.001	3	4
CCRCC	ARHGEF6_S640 →	+0.858	+0.700	.001	.001	3	4
HNSC	RCSD1 →	+0.620	+0.759	<.001	.001	3	3
HNSC	RCSD1_S298 →	+0.570	+0.480	<.001	.005	3	3
HNSC	ARRB1 →	+0.451	+0.780	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,711 associations by consensus.

PRSS2 vs RGS14 — HNSC

Explore this scatter interactively →