PRSS2

Across TCGA patient cohorts, PRSS2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,176 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PRSS2-associated genes across cancer lineages are PRSS1, TIGD7, and ENGASE. Each is linked with PRSS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRSS2-to-partner and partner-to-PRSS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRSS2 versus PRSS1 in PDAC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS2→partner) and Y-score (partner→PRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRSS1 →	+4.516	+0.867	<.001	<.001	3	4
LUAD	TIGD7 →	-0.456	-1.338	<.001	<.001	3	2
COAD	ENGASE →	-0.972	-1.159	.002	.004	3	2
UCEC	LRRC2-AS1 →	-0.482	-1.125	.004	.001	3	2
LUAD	S100PBP →	-0.324	-1.440	.001	.003	3	2
LUAD	RPAP2 →	-0.436	-1.753	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,176 associations by consensus.

PRSS2 vs PRSS1 — PDAC

Explore this scatter interactively →