PRSS2

Across TCGA cell cohorts, PRSS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,021 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PRSS2-associated GO terms across cancer lineages are Positive regulation of catecholamine secretion, Vascular endothelial growth factor receptor signaling pathway, and Negative regulation of actin nucleation. Each is linked with PRSS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRSS2-to-partner and partner-to-PRSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of catecholamine secretion grouped by PRSS2-low versus PRSS2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS2→partner) and Y-score (partner→PRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of catecholamine secretion →	+0.249	+2.791	<.001	.008	3	6
LARGE_INTESTINE	Vascular endothelial growth factor receptor signaling pathway →	+0.119	+1.856	<.001	.009	3	4
LARGE_INTESTINE	Negative regulation of actin nucleation →	+0.116	+1.918	.001	.007	3	4
SOFT_TISSUE	Regulation of chromatin organization →	+0.054	+0.119	.001	.003	3	4
PANCREAS	Regulation of Rho protein signal transduction →	+0.086	+3.432	<.001	.001	3	4
LUNG_SCLC	Exocytosis →	+0.048	+2.893	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,021 associations by consensus.

Positive regulation of catecholamine secretion by PRSS2 expression — PANCREAS

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