PRSS12

Across TCGA patient cohorts, PRSS12 mutation is significantly associated with the RNA expression of many other genes, with 4,150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS12-associated genes across cancer lineages are GINS4, H2AZ1, and MCM6. Each is linked with PRSS12 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRSS12-to-partner and partner-to-PRSS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS4 grouped by PRSS12-low versus PRSS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS12→partner) and Y-score (partner→PRSS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS4 →	+0.507	+1.484	.006	.004	3	4
SKCM	H2AZ1 →	+0.561	+2.267	<.001	.001	3	4
SKCM	MCM6 →	+0.663	+1.854	<.001	.005	3	4
UCEC	MTHFD1 →	+0.429	+2.021	.001	.005	3	3
UCEC	RBBP8 →	+0.667	+2.513	<.001	<.001	3	3
UCEC	NEIL3 →	+0.456	+2.923	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,150 associations by consensus.

GINS4 by PRSS12 expression — UCEC

Explore this box plot interactively →