PRRX2

Across TCGA patient cohorts, PRRX2 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PRRX2-associated genes across cancer lineages are IGHD5-24, FAM197Y1, and RNU6-128P. Each is linked with PRRX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRX2-to-partner and partner-to-PRRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-24 grouped by PRRX2-low versus PRRX2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX2→partner) and Y-score (partner→PRRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGHD5-24 →	+1.697	+5.669	<.001	.003	3	2
UCEC	FAM197Y1 →	+0.049	+8.066	<.001	.007	3	2
CESC	RNU6-128P →	+0.337	+5.306	<.001	.006	3	1
CESC	IGHD1-14 →	+1.146	+5.539	<.001	.004	3	1
CESC	GXYLT1P7 →	+0.039	+5.306	.004	.006	3	1
CESC	PPP1R12BP1 →	+0.022	+5.969	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

IGHD5-24 by PRRX2 expression — CESC

Explore this box plot interactively →