PRRX2

Across TCGA cell cohorts, PRRX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,337 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRRX2-associated GO terms across cancer lineages are Protein folding, Mitochondrial electron transport, cytochrome c to oxygen, and Negative regulation of cGAS/STING signaling pathway. Each is linked with PRRX2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRRX2-to-partner and partner-to-PRRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein folding grouped by PRRX2-low versus PRRX2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX2→partner) and Y-score (partner→PRRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein folding →	+0.094	+1.970	<.001	<.001	3	10
STOMACH	Mitochondrial electron transport, cytochrome c to oxygen →	+0.105	+1.005	<.001	.008	3	9
LIVER	Negative regulation of cGAS/STING signaling pathway →	+0.083	+1.826	<.001	.002	3	9
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.128	+1.060	.002	.006	2	9
OESOPHAGUS	DNA-templated transcription initiation →	+0.066	+1.496	.002	<.001	3	8
OESOPHAGUS	Transcription initiation at RNA polymerase II promoter →	+0.060	+1.384	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,337 associations by consensus.

Protein folding by PRRX2 expression — OESOPHAGUS

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