PRRX2

Across TCGA cell cohorts, PRRX2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRRX2-associated genes across cancer lineages are LGI1 and C6orf118. Each is linked with PRRX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRX2-to-partner and partner-to-PRRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by PRRX2-low versus PRRX2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX2→partner) and Y-score (partner→PRRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.139	+5.539	<.001	.003	3	1
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

LGI1 by PRRX2 expression — BLOOD_Leukemia

Explore this box plot interactively →