PRRX1

Across TCGA pan-cancer cohorts, PRRX1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRRX1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PRRX1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PRRX1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where PRRX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.777	0.975	.013	21	view →
PDAC	DFS	Tertile	II,III,IV	0.239	0.469	.004	17	view →
CCRCC	DFS	Median	II,III,IV	0.870	0.284	.014	14	view →
GBM	OS	Quartile	All	0.728	0.975	.003	5	view →
LUAD	OS	Median	III,IV	0.344	0.897	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRRX1–LSCC (OS)

Open the LSCC breakdown →