PRRX1

Across TCGA patient cohorts, PRRX1 mutation is significantly associated with the RNA expression of many other genes, with 3,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRX1-associated genes across cancer lineages are VCPKMT, RN7SL728P, and RNA5SP340. Each is linked with PRRX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRX1-to-partner and partner-to-PRRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCPKMT grouped by PRRX1-low versus PRRX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX1→partner) and Y-score (partner→PRRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VCPKMT →	+0.393	+2.906	.004	.001	3	3
HNSC	RN7SL728P →	+0.103	+4.608	<.001	.005	3	3
HNSC	RNA5SP340 →	+0.236	+3.556	.002	.007	3	3
SKCM	PPP2R5E →	+0.518	+2.719	.008	.003	3	3
UCEC	RTRAF →	+0.388	+3.917	<.001	<.001	3	3
BLCA	RPL9P13 →	+0.145	+5.106	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,955 associations by consensus.

VCPKMT by PRRX1 expression — UCEC

Explore this box plot interactively →