PRRX1

Across TCGA patient cohorts, PRRX1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRX1-associated genes across cancer lineages are p27_pT198, PCNA, and Shc_pY317. Each is linked with PRRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRX1-to-partner and partner-to-PRRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by PRRX1-low versus PRRX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX1→partner) and Y-score (partner→PRRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.089	+3.321	.033	.010	3	2
UCEC	PCNA →	+0.259	+3.169	.002	.018	3	2
UCEC	Shc_pY317 →	-0.226	-3.459	<.001	.005	3	2
UCEC	STAT3_pY705 →	-0.384	-1.584	<.001	.036	3	2
UCEC	c-Kit →	-0.194	-2.000	.034	.010	3	2
UCEC	4E-BP1 →	+0.397	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

p27_pT198 by PRRX1 expression — UCEC

Explore this box plot interactively →