PRRX1

Across TCGA cell cohorts, PRRX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,911 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PRRX1-associated GO terms across cancer lineages are Positive regulation of chromosome organization, Nuclear transport, and DNA damage tolerance. Each is linked with PRRX1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PRRX1-to-partner and partner-to-PRRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome organization grouped by PRRX1-low versus PRRX1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX1→partner) and Y-score (partner→PRRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of chromosome organization →	+0.072	+2.564	<.001	.001	2	8
PANCREAS	Nuclear transport →	+0.089	+0.233	<.001	<.001	3	7
SKIN	DNA damage tolerance →	+0.062	+2.092	.002	.002	3	6
CNS	Regulation of collagen metabolic process →	+0.102	+2.476	.001	<.001	3	6
BREAST	Paranodal junction assembly →	-0.246	-1.208	<.001	.001	3	6
OVARY	Protein depolymerization →	+0.086	+1.299	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,911 associations by consensus.

Positive regulation of chromosome organization by PRRX1 expression — SKIN

Explore this box plot interactively →