PRRX1

Across TCGA cell cohorts, PRRX1 mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRX1-associated genes across cancer lineages are EVPLL, C20orf85, and PRLH. Each is linked with PRRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRX1-to-partner and partner-to-PRRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVPLL grouped by PRRX1-low versus PRRX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRX1→partner) and Y-score (partner→PRRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EVPLL →	+0.536	+3.347	<.001	.006	3	2
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	2
SKIN	PRLH →	+0.227	+5.022	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.760	+3.451	<.001	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.713	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

EVPLL by PRRX1 expression — LARGE_INTESTINE

Explore this box plot interactively →