Across TCGA patient cohorts, PRRT4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRT4-associated genes across cancer lineages are Bax, Annexin-1, and PCNA. Each is linked with PRRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRT4-to-partner and partner-to-PRRT4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT4→partner) and Y-score (partner→PRRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Bax →	+0.257	+2.815	.037	.036	3	2
UCEC	Annexin-1 →	+0.656	+2.807	.004	.003	3	2
COAD	PCNA →	+0.298	+2.815	.028	.036	2	2
UCEC	A-Raf_pS299 →	-0.140	-2.807	.007	.003	3	1
UCEC	Heregulin →	-0.157	-3.584	.003	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.246	-3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

PRRT4 survival (RNA) · tumor vs normal (RNA) · all PRRT4 data types