PRRT3

Across TCGA pan-cancer cohorts, PRRT3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRRT3 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PRRT3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRRT3 expression acts as an unfavorable survival marker.

KICH, ESCA, and COAD are the cancer types where PRRT3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.081	0.904	<.001	30	view →
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →
COAD	DFS	Median	All	0.404	0.701	.017	6	view →
GBM	OS	Median	All	0.104	0.415	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRRT3–KICH (DFS)

Open the KICH breakdown →