PRRT3

Across TCGA patient cohorts, PRRT3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRT3-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and Myosin-IIa_pS1943. Each is linked with PRRT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRT3-to-partner and partner-to-PRRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRRT3-low versus PRRT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT3→partner) and Y-score (partner→PRRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.798	+1.894	.001	.030	3	3
UCEC	ERK2 →	+0.262	+2.321	<.001	.006	3	2
UCEC	Myosin-IIa_pS1943 →	+0.181	+2.335	.033	.003	3	2
UCEC	PI3K-p85 →	+0.185	+2.469	.032	.010	3	2
COAD	TAZ →	+0.227	+2.832	.035	.035	3	2
UCEC	14-3-3_beta →	-0.086	-2.973	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Caspase-7-cleavedD198 by PRRT3 expression — UCEC

Explore this box plot interactively →