PRRT2

Across TCGA patient cohorts, PRRT2 mutation is significantly associated with the RNA expression of many other genes, with 569 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRT2-associated genes across cancer lineages are RN7SL813P, NF1P10, and MTND4LP20. Each is linked with PRRT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRT2-to-partner and partner-to-PRRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL813P grouped by PRRT2-low versus PRRT2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT2→partner) and Y-score (partner→PRRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL813P →	+0.158	+5.221	<.001	.003	3	3
CESC	NF1P10 →	+0.289	+4.984	<.001	.003	3	2
CESC	MTND4LP20 →	+0.100	+5.579	<.001	.001	3	2
HNSC	TAS2R7 →	+0.043	+4.912	.006	.005	3	2
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	2
BLCA	GCNAP1 →	+0.710	+3.937	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 569 associations by consensus.

RN7SL813P by PRRT2 expression — HNSC

Explore this box plot interactively →