PRRT2

Across TCGA patient cohorts, PRRT2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRT2-associated genes across cancer lineages are FASN, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with PRRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRT2-to-partner and partner-to-PRRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PRRT2-low versus PRRT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT2→partner) and Y-score (partner→PRRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.387	+3.087	.014	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.105	-1.906	.037	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.210	-3.459	.001	.005	3	1
UCEC	MAPK_pT202_Y204 →	-0.464	-2.584	.014	.010	3	1
UCEC	MEK1_p_S217_S221 →	-0.248	-2.000	.024	.030	3	1
UCEC	MSH6 →	-0.388	-3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FASN by PRRT2 expression — UCEC

Explore this box plot interactively →