PRRT2

Across TCGA cell cohorts, PRRT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,275 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PRRT2-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Viral translational termination-reinitiation, and Regulation of myoblast fusion. Each is linked with PRRT2 in more than 14 cancer types. Because this analysis shows association rather than direction, both PRRT2-to-partner and partner-to-PRRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by PRRT2-low versus PRRT2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT2→partner) and Y-score (partner→PRRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Calcium-independent cell-matrix adhesion →	+0.208	+2.623	<.001	<.001	3	15
BONE	Viral translational termination-reinitiation →	+0.092	+2.714	<.001	<.001	3	15
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.103	+1.211	<.001	<.001	3	15
STOMACH	Negative regulation of myoblast fusion →	+0.103	+0.845	<.001	.008	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.120	+0.694	<.001	.002	3	15
BONE	Lipoprotein transport →	+0.211	+2.223	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,275 associations by consensus.

Calcium-independent cell-matrix adhesion by PRRT2 expression — LUNG_SCLC

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