PRRT2

Across TCGA cell cohorts, PRRT2 mutation is significantly associated with the mutation status of many other genes, with 2,043 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRRT2-associated genes across cancer lineages are TALDO1, SPRY4, and ZNF513. Each is linked with PRRT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRT2-to-partner and partner-to-PRRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TALDO1 grouped by PRRT2-low versus PRRT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT2→partner) and Y-score (partner→PRRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TALDO1 →	+4.523	+5.087	.006	.006	1	3
LARGE_INTESTINE	SPRY4 →	+5.523	+5.523	.003	.003	1	3
UPPER_AERODIGESTIVE_TRACT	ZNF513 →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	EPN1 →	+5.392	+5.392	.004	.004	1	3
BLOOD_Leukemia	RBL1 →	+4.560	+4.870	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	USP40 →	+4.392	+4.954	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,043 associations by consensus.

TALDO1 by PRRT2 expression — LARGE_INTESTINE

Explore this box plot interactively →